My favorite in the series is still AC: Odyssey and I'm baffled that they aren't making AC:Rome or a direct sequel/prequel (either Alexander's Greece or Roman Empire Greece/Byzantine), to reuse the digital map. I don't want endless sequels, but Ancient Greece, Rome and Egypt are kind of the best setting for this series. Ancient Japan is cool, and so would ancient/medieval China be.
An an American, I don't really want another Wild West game, it's been done to death. It would feel like a rerun more than a sequel to AC: Odyssey, imo.
I find it very odd that they don't want to save money and reuse their best settings. I appreciate it on one level, but I want more of Rome/Greece.