In the absence of the Galaxy Note series, Samsung's Galaxy S series has taken up the mantle of being the smartphone maker's premium mainstream devices. The status quo may yet be upset, however, in light of recent Galaxy A73 leaks.
https://www.notebookcheck.net/The-Galaxy-A73-could-be-Samsung-s-phone-to-watch-out-for-in-2022.562233.0.html
If Samsung include DeX capability for the top-range A series model, that would be a worthy purchase. LG had shown before that it was possible to have a pocket PC experience from an upper midrange smartphone with the Velvet 5G and the Wing 5G.
One feature I would quite like to see crop up on an A-series phone would be wireless charging, it is handy for topping up my phone when it is just sitting on my desk and doesn't seem to show up in the midrange that still has the features I want like headphone sockets and sd card slots.